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Receipt of research or educational grants: Genzyme Canada, Merck Serono I have no conflicts of interest - Carolina Rushįunding disclosures for Carolina Rush and Reshmi Roy: There were no clinical features that were specific to patients with LOMS and VLOMS that were found, that predict disability progression.ĭisclosure: I have no conflicts of interest. The average time from symptom onset to diagnosis was found to be 17.50 months based on 87 patients out of 121 for whom this was recorded.Ĭonclusion: There are differences between the first onset syndromes experienced by patients with younger onset MS versus later onset MS. Mean EDSS scores at diagnosis were 2.54+/-1.60 for 114 patients that had EDSS scores recorded at diagnosis. Optic neuritis was the least common initial syndrome at presentation (8 patients). The most common syndrome at initial presentation in our population was a transverse myelitis (81 patients, 53% with thoracic myelitis and 47% with cervical myelitis). Results: Of 121 patients, the mean age of onset of symptoms was 55.65+/-4.83. Demographic features, Cerebrospinal fluid, lesion burden on MRI, first onset symptoms/syndrome, EDSS scores at diagnosis, mean time to reach diagnosis, and the frequency of MS subtypes were reviewed. Methods: A retrospective analysis was performed on 121 participants from the Ottawa Hospital MS clinic IMED database, with LOMS, or VLOMS or a clinically isolated syndrome based on the Mcdonald 2010 criteria. Purpose: The objective of this study was to identify the incidence of late onset MS (LOMS) and very late onset MS (VLOMS) in our local MS database, and to determine which clinical characteristics were most commonly seen amongst this population and whether there were specific clinical characteristics that could predict disability progression. There is very little literature on the clinical characteristics of patients with late and very late onset MS.
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Neurology, The Ottawa Hospital and the University of Ottawa, Ottawa, ON, Canadaįirst onset of Multiple sclerosis (MS) symptoms in those over age 50 (late onset MS) and 60 (very late onset MS) is very rare. Our results, which indicate that in LOMS patients brain tissue damage is more advanced than in TOMS patients, may contribute to a better understanding of the heterogeneity of MS.Abstract Category: Clinical aspects of MS - Epidemiology MRI parameters in patients with LOMS differed significantly from those obtained from the TOMS group. We did not find a statistical difference in T1- and T2- lesion load (p = 0.1, p = 0.3 respectively) although T1/T2 lesion ratio was higher in the LOMS group.Ĭonclusion and clinical implications. No statistical difference was found between the groups in terms of mean mIn (p = 0.346) and mean GPC+PCh (p = 0.563). Patients with LOMS experience more motor symptoms compared with AOMS. Patients with LOMS manifested lower concentrations of NAA+NAAG and NAA+NAAG/Cr than patients with TOMS (p = 0.009 and p < 0.001 respectively). He was diagnosed with late-onset multiple sclerosis (LOMS), and was treated with. Patients with LOMS and TOMS statistically differed in the peak height (p = 0.018), peak location (p < 0.001), and MTR mean value (p < 0.001). There was no statistical differences in White Matter Fraction (WMF) values between the groups (p = 0.572). Patients with late onset of MS had lower Brain Parenchyma Fraction (BPF) (p < 0.001) and Grey Matter Fraction (GMF) values (p = 0.008) than the TOMS group. Parameters from both techniques were compared between LOMS and TOMS groups. Conventional (T1- and T2-weighted images) and non-conventional (magnetization transfer images, proton magnetic resonance spectroscopy) MRI techniques were performed in all participants. The two groups were matched in terms of disease duration and EDSS score. Twenty patients with LOMS were included in the study and 17 patients with typical onset of MS (TOMS) served as a comparative group. To investigate the MRI characteristics of LOMS patients based on conventional and non-conventional techniques. Neither conventional nor nonconventional MRI features are known to be typical for LOMS.Ĭlinical rationale for the study. Also the MRI characteristics of patients with LOMS have not been determined. Until now, the differences in clinical course, type of first symptoms, and prognosis of LOMS have not been well established.
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This type of MS is called Late Onset Multiple Sclerosis (LOMS). Clinically definite multiple sclerosis (CDMS) can occur also in patients older than 50 years. Typical age of onset is between 20 and 35 years. Multiple sclerosis (MS) is a demyelinating disease of the central nervous system (CNS) with heterogenic character.